Endocrine Abstracts

Objectives: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic ones (sMTC). We examined the presentation of these entities in our centre.Methods: 223 MTC patients (familial: 42.6%, males: 36.8%) were followed for 0.9–30 years (mean 6.23±5.9, median 4.0 years). 44 (19.7%) fMTC patients were operated after genetic screening.Results: Median age at diagnosi...

Objectives: In familial MTC there is genotype-phenotype correlation. The phenotype and clinical outcome in exon8 (G533C) carriers has not been well established.Methods: 95 patients operated for familial MTC (27.2% males) were followed for 0.9–30 years (mean 8.0, median 5.5 years). 45.3% (n=43) were exon8 carriers (exon8MTC) and the remaning were non-exon8MTCs (n=52, exons 10, 11, 13, 14, and 16). Pre-, postoperative calcitonin, ext...

Introduction: Differentiated thyroid carcinoma (DTC) has generally a good prognosis and is associated with prolonged survival. A minority of patients may have persistent disease and rarely aggravation during f/u. We investigated factors which may influence the persistence of disease in patients who had undergone ablation with I131.Patients and methods: 903 DTC patients were referred in our center from 1968 to 2012. Five hundred and forty-one (...

Introduction: Recently, small medullary thyroid carcinomas (sMTCs) (≤1.5 cm) are frequently diagnosed, occasionally as incidental findings in surgical and autopsy specimens. Their clinical course varies. We examined whether tumor size is a predictor of clinical behavior.Patients and methods: One hundred and one sMTC patients (36.6% males, 47.1% familial) followed-up for 0.9–35 years. Patients were classified according to tumor size (cm) in gro...

Background: TSH levels within the normal range have been associated with increased blood pressure (BP). TSH itself might be involved, especially as extrathyroidal actions of TSH exist.We investigated whether elevated TSH levels after acute rhTSH administration may result in alterations in BP in euthyroid individuals.Methods: Twenty-six euthyroid female subjects thyroidectomised and on T4 suppressive dose, were evaluated ...